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ISO-CHEK®

Complete Isocyanate Sampling System

ISO-CHEK Sampling Cassette for Isocyanates 225-9022

  • Accurately samples diisocyanates: HDI, MDI, IPDI, HMDI, 2,4-TDI, and 2,6-TDI


  • The only filter-based sampling system that simultaneously traps and separates both monomers and oligomers
    • Enhanced detection of toxic risk


  • Decreases sample preparation and analysis time by 40% compared to other methods
    • Pre-made calibration standards are available


  • Highly stable — minimizes storage and handling


  • Highly sensitive analysis provides detection limits below current regulated exposure levels
    • Ideal for occupational sampling and environmental surveys
    • Requires only a 15-minute sample time


  • ISO-CHEK-certified laboratories** ensure accurate and consistent isocyanate analysis


  • Meets the specifications of several methods
    • ASTM D5932-96 2,4, 2,6-TDI (monomer)
    • ASTM D6561-00 HDI (aerosol oligomer), the only U.S. standard for oligomers
    • ASTM D6562-00 HDI (gaseous monomer)

ISO-CHEK Isocyanate Sampling System Product Data Bulletin (PDF)

The patented ISO-CHEK Isocyanate Sampling System is a preloaded 3-piece cassette that contains two stages. Stage one contains an untreated PTFE (Teflon®) filter to collect the aerosol phase and stage two holds a glass fiber filter impregnated with 9-(N-methylaminomethyl) anthracene (MAMA) for the vapor phase of isocyanates. This system effectively traps and separates the phases at the point of collection and offers many advantages over other methods for sampling isocyanates.

The ISO-CHEK Advantage!

Simultaneous collection and separation of phases at the point of collection: ISO-CHEK separates the vapor and aerosol phases at the point of collection for less time-consuming and more accurate analysis of each phase.

Reagent and samples are stable at room temperature: Degradation of samples or loss of derivatizing reagent was found under ambient conditions was found when using other methods.

15-minute sampling time: Isocyanates are sensitizing agents. Even short 15-minute exposures at high concentrations can lead to sensitivity in susceptible individuals. Therefore, short-term sampling provides more meaningful results than the longer sampling times required by other methods.

No handling precautions: no refrigeration of the cassette, derivatizing reagent, or sample is required. ISO-CHEK is safe to use — no broken glass or splashing impinger liquid.


ISO-CHEK cassette 225-9022 Exploded View
ISO-CHEK cassette 225-9022 Exploded View

 

Principle of Operation

A sample pump draws air through the ISO-CHEK cassette. Aerosols are trapped on the PTFE filter while gases pass through to the next filter. Vapors are trapped on the fiber glass filter impregnated with MAMA. A chemical reaction occurs on this filter resulting in the formation of a highly detectable urea derivative. The PTFE filter is derivatized in the field by placing it in a supplied jar, containing Methoxy-2-phenyl-1 piperazine reagent (MOPIP). Monomeric and oligomeric phases are separated by using a reverse phase HPLC column with a UV detector and fluorescence detector in series.

Using ISO-CHEK

Simply unplug and connect the cassette to a calibrated sample pump capable of at least 1 L/min. Take a 15-minute sample. Immediately after sampling, open the cassette, remove the PTFE filter with forceps, match the cassette ID number with the reagent jar number, and place the filter in the prepared reagent jar. The fiber glass filter remains in the cassette. Replug the cassette, wrap it in foil to protect the sample from light, and ship the jar and cassette to an ISO-CHEK-certified laboratory *.

Comparison of ISO-CHEK to Other Methods

Parameter ISO-CHEK OSHA
Method 42 1
NIOSH
Method 5521 2
Collection Technique Dual filter cassette Single filter cassette Impinger
Monomer and Oligomer Separation Simultaneously collects and separates phases Separation is performed during analysis Separation is performed during analysis
HDI, TDI Monomer Free from Matrix Interference Yes No No
Derivatizing Reagent MAMA 3 1-2 PP 4 2-MP 5
Stable Reagent at room temperature Yes No 6 No 7
Handling Precautions None Refrigerate Refrigerate
Analysis Method Reverse phase HPLC with UV, FD Reverse phase HPLC with UV, FD Reverse phase HPLC with UV, ECD
Sample Collection Time (in minutes) 15 60 15 - 240
Sample Prep and Analysis Time (in minutes) 45 75 75

Quantitation Limit 8
(10 sigma 2)

2,6-TDI

2,4-TDI

1,6-HDI

MDI

 

1.0

1.0

1.0

1.0/0.27

 

2.3

2.5

2.9

NA

 

0.5

0.7

1.0

0.3

Limit of Detection 9
(3 sigma 2)

2,6-TDI

2,4-TDI

1,6-HDI

MDI

 

0.2

0.2

0.6

0.3/0.08

 

1.6

1.3

2.3

NA

 

0

0.1

0.1

0.1

Analysis Precision (CV) 0.02 0.009 Unknown 10
Range Tested for Precision (mg/m3) 1 - 280 70 - 280 NA 11
Reproducibility/Accuracy 12 100.3 - 100.6 100.5 - 105.4 NA
% Recovery SD 1 - 1.6 1.6 - 2.4 NA

Download Technical Note PDF Comparison of ISO-CHEK Method Parameters and Reagent Stability

References


Ordering Information           Online Ordering

Description Quantity Cat. No.

ISO-CHEK* Sampling System preloaded clear cassettes for isocyanates
ISO-CHEK cassettes require derivatizing solution (see below) and Sure-Seal Cassette Opene 225-13-5A

12 225-9022
36 225-9022A
ISO-CHEK* Sampling System with Derivatizing Reagent preloaded clear cassettes and jars of derivatizing agent
ISO-CHEK cassettes require derivatizing solution (see below) and Sure-Seal Cassette Opene 225-13-5A
4
225-9023
10 225-9023A
ISO-CHEK Standards Set, includes HDI, MDI, IPDI, 2,4 TDI, and 2,6 TDI, 1 gram each, set of 5
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC.
12 jars 225-9050

Sure-Seal Cassette Opener , stainless steel, opens 25- and 37-mm cassettes (included in Filter Handling Kit 225-8372)

required for ISO-CHEK cassettes

Cassette Opener, stainless steel 225-13-5A 1 225-13-5A
Jars,
glass with Teflon®-lined caps, for solvent extraction of filters
Jar 225-8376 8 225-8376
36 225-8377
ISO-CHEK Calibration Standard Set, calibration standards for HDI, MDI, IPDI, 2,4-TDI, and 2,6-TDI, 1 gram each
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC.
set 225-9055
ISO-CHEK Calibration Standard, MAMA-HMDI concentrate
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC.
1 225-9056
ISO-CHEK Calibration Standard, 2,4 TDI and 2,6 TDI, 1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC.
1 225-9052
ISO-CHEK Calibration Standard, HDI, 1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC.
1 225-9053
ISO-CHEK Calibration Standard, IPDI, 1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC.
1 225-9054
ISO-CHEK Calibration Standard, MDI, 1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC.
1 225-9062
ISO-CHEK Packaging Kit , provides shipping material to make 10 packaging kits each holding 10 samplers and derivatizing solution jars 1 225-9059
ISO-CHEK Packaging Kit includes shipping material to make 20 packages; each holding 4 ISO-CHEK samplers and 4 derivatizing solution jars 1 225-9063
ISO-CHEK Certified HPLC Column ODS-1, measures vapor and aerosol fractions of HDI, 2,4-TDI, and 2,6-TDI, provides a threefold increase in sensitivity over conventional columns while requiring only 1/3 of the solvent 1 225-9057
ISO-CHEK Certified HPLC Column ODS-2 for the determination of MDI oligomers. Provides a threefold increase in sensitivity over conventional columns, while requiring only a 1/3 of the solvent. 1 225-9060
ISO-CHEK Column Guard ODS-1, used to protect ISO-CHEK HPLC column ODS-1 from premature plugging 1 225-9058
* ISO-CHEK cassettes must be analyzed by an ISO-CHEK-certified laboratory. For a lab list see the SKC ISO-CHEK Cassettes Laboratory Reference List.
Haz-Mat shipping charges for air shipments only, ground shipments exempt; not available for export.
Patent No. 4,961,916
IRSST (Institut de recherche en santé et en sécurité du travail du Québec)

 

ISO-CHEK Isocyanate Sampling System Product Data Bulletin (PDF)

Material Safety Data Sheets

MSDS — MOPIP 1-(2-Methoxyphenyl) Piperazine

MSDS — MAMA 9-(Methylaminomethyl) Anthracene

MSDS — Toluene


References

1 OSHA Method 42 for the analysis of diisocyanates

2 NIOSH Method 5221, Monomeric Isocyanates

3 9-(N-methylaminomethyl) anthracene

4 1-(2-Pyridyl) piperazine

5 1-(2-Methoxypyridyl) piperazine

6 Poster Session, 1996 AIHce, Paper #398: Meyer, P. and Czarnecki, M.

7 NIOSH Method 5221, Monomeric Isocyanates

8, 9 Detection limits for ISO-CHEK and OSHA Method 42 are µg/m3 in a 15-liter sample. For NIOSH Method 5521, limits are stated as "per sample" with sample volume range given as 5 to 500 liters, and limits were established using pure standards without derivatizing reagent. For MDI, the first number of the pair for ISO-CHEK is with a UV detector, the second is with a fluorescence detector.

10, 11 NIOSH Method 5221, Monomeric Isocyanates

12 Recovery of spiked standards by analysts is not associated with method

NA Data not available or determined

® ISO-CHEK is a registered trademark of Omega Speciality Instrument Co.


This page was last modified March 6, 2007
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