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ISO-CHEK®
Complete Isocyanate Sampling System
- Accurately samples diisocyanates: HDI, MDI, IPDI,
HMDI, 2,4-TDI, and 2,6-TDI
- The only filter-based sampling system that
simultaneously traps and separates both
monomers and oligomers
- Enhanced detection of toxic risk
- Decreases sample preparation and analysis time
by 40% compared to other methods
- Pre-made calibration standards are available
- Highly stable — minimizes storage and handling
- Highly sensitive analysis provides detection limits
below current regulated exposure levels
- Ideal for occupational sampling and environmental surveys
- Requires only a 15-minute sample time
- ISO-CHEK-certified laboratories** ensure accurate
and consistent isocyanate analysis
- Meets the specifications of several methods
- ASTM D5932-96 2,4, 2,6-TDI (monomer)
- ASTM D6561-00 HDI (aerosol oligomer), the only U.S. standard for oligomers
- ASTM D6562-00 HDI (gaseous monomer)
ISO-CHEK
Isocyanate Sampling System Product Data Bulletin (PDF)
The patented • ISO-CHEK
Isocyanate Sampling System is a preloaded 3-piece cassette that contains
two stages. Stage one contains an untreated PTFE (Teflon®) filter to
collect the aerosol phase and stage two holds a glass fiber filter
impregnated with 9-(N-methylaminomethyl) anthracene (MAMA)
for the vapor phase of isocyanates.
This system effectively traps and separates the phases at the point
of collection and offers many advantages over other methods for sampling
isocyanates.
The ISO-CHEK Advantage!
Simultaneous collection and separation of phases at the point
of collection: ISO-CHEK
separates the vapor and aerosol phases at the point of collection
for less time-consuming and more accurate analysis of each phase.
Reagent and samples are stable at room temperature: Degradation
of samples or loss of derivatizing reagent was found under ambient
conditions
was found when using other methods.
15-minute sampling time: Isocyanates are sensitizing
agents. Even short 15-minute exposures at high concentrations can lead to
sensitivity in susceptible individuals.
Therefore, short-term sampling provides more meaningful results than the
longer sampling times required by other methods.
No handling precautions: no refrigeration
of the cassette, derivatizing reagent, or sample is required. ISO-CHEK is
safe to use — no broken glass or splashing impinger liquid.
Principle of Operation
A sample pump draws air through the ISO-CHEK cassette. Aerosols
are trapped on the PTFE filter while gases pass through to the next
filter. Vapors are trapped on the fiber glass filter impregnated
with MAMA. A chemical reaction occurs on this filter resulting in
the formation of a highly detectable urea derivative. The PTFE filter
is derivatized in the field by placing it in a supplied jar, containing
Methoxy-2-phenyl-1 piperazine reagent (MOPIP). Monomeric and oligomeric
phases are separated by using a reverse phase HPLC column with a
UV detector and fluorescence detector in series.
Using ISO-CHEK
Simply unplug and connect the cassette to a calibrated sample pump
capable of at least 1 L/min. Take a 15-minute sample. Immediately
after sampling, open the cassette, remove the PTFE filter with forceps,
match the cassette ID number with the reagent jar number, and place
the filter in the prepared reagent jar. The fiber glass filter remains
in the cassette. Replug the cassette, wrap it in foil to protect
the sample from light, and ship the jar and cassette to an ISO-CHEK-certified
laboratory *.
Comparison of ISO-CHEK to Other Methods
| Parameter |
ISO-CHEK |
OSHA
Method 42 1 |
NIOSH
Method 5521 2 |
| Collection Technique |
Dual filter cassette |
Single filter cassette |
Impinger |
| Monomer and Oligomer Separation |
Simultaneously collects and separates phases |
Separation is performed during analysis |
Separation is performed during analysis |
| HDI, TDI Monomer Free from Matrix Interference |
Yes |
No |
No |
| Derivatizing Reagent |
MAMA 3 |
1-2 PP 4 |
2-MP 5 |
| Stable Reagent at room temperature |
Yes |
No 6 |
No 7 |
| Handling Precautions |
None |
Refrigerate |
Refrigerate |
| Analysis Method |
Reverse phase HPLC with UV, FD |
Reverse phase HPLC with UV, FD |
Reverse phase HPLC with UV, ECD |
| Sample Collection Time (in minutes) |
15 |
60 |
15 - 240 |
| Sample Prep and Analysis Time (in minutes) |
45 |
75 |
75 |
Quantitation Limit 8
(10 sigma 2)
2,6-TDI
2,4-TDI
1,6-HDI
MDI
|
1.0
1.0
1.0
1.0/0.27
|
2.3
2.5
2.9
NA
|
0.5
0.7
1.0
0.3
|
|
Limit of Detection 9
(3 sigma 2)
2,6-TDI
2,4-TDI
1,6-HDI
MDI
|
0.2
0.2
0.6
0.3/0.08
|
1.6
1.3
2.3
NA
|
0
0.1
0.1
0.1
|
| Analysis Precision (CV) |
0.02 |
0.009 |
Unknown 10 |
| Range Tested for Precision (mg/m3) |
1 - 280 |
70 - 280 |
NA 11 |
| Reproducibility/Accuracy 12 |
100.3 - 100.6 |
100.5 - 105.4 |
NA |
| % Recovery SD |
1 - 1.6 |
1.6 - 2.4 |
NA |
Download Technical Note
PDF Comparison of ISO-CHEK Method Parameters and Reagent Stability
References
Ordering Information Online
Ordering
| Description |
Quantity |
Cat. No. |
ISO-CHEK* Sampling
System preloaded clear cassettes for isocyanates
ISO-CHEK cassettes require derivatizing solution
(see below) and Sure-Seal Cassette Opene 225-13-5A
|
12 |
225-9022 |
| 36 |
225-9022A |
ISO-CHEK* Sampling
System with Derivatizing Reagent ‡ preloaded
clear cassettes and jars of derivatizing agent
ISO-CHEK cassettes require derivatizing solution
(see below) and Sure-Seal Cassette Opene 225-13-5A |
4 |
225-9023 |
| 10 |
225-9023A |
ISO-CHEK Standards Set, includes
HDI, MDI, IPDI, 2,4 TDI, and 2,6 TDI, 1 gram each, set of 5
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC. |
12 jars |
225-9050 |
Sure-Seal Cassette Opener ,
stainless steel, opens 25- and 37-mm cassettes
(included in Filter Handling Kit 225-8372)
required
for ISO-CHEK cassettes
|
 |
1 |
225-13-5A |
Jars,
glass with Teflon®-lined caps, for solvent extraction of filters |
 |
8 |
225-8376 |
| 36 |
225-8377 |
ISO-CHEK Calibration Standard
Set, calibration
standards for HDI, MDI, IPDI, 2,4-TDI, and 2,6-TDI, 1 gram each
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other
ISO-CHEK standards are available. Contact SKC. |
set |
225-9055 |
ISO-CHEK Calibration Standard, MAMA-HMDI concentrate
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC. |
1 |
225-9056 |
ISO-CHEK Calibration Standard, 2,4
TDI and 2,6 TDI, 1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC. |
1 |
225-9052 |
ISO-CHEK Calibration Standard, HDI,
1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC. |
1 |
225-9053 |
ISO-CHEK Calibration Standard, IPDI,
1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC. |
1 |
225-9054 |
ISO-CHEK Calibration Standard, MDI,
1 gm
Limited shelf life. Freezer storage recommended.
Does NOT require refrigerated shipping.
Other ISO-CHEK standards are available. Contact SKC. |
1 |
225-9062 |
| ISO-CHEK Packaging Kit , provides
shipping material to make 10 packaging kits each holding 10 samplers
and derivatizing solution jars |
1 |
225-9059 |
| ISO-CHEK Packaging Kit includes
shipping material to make 20 packages; each holding 4 ISO-CHEK
samplers and 4 derivatizing solution jars |
1 |
225-9063 |
| ISO-CHEK Certified HPLC Column ODS-1,
measures vapor and aerosol fractions of HDI, 2,4-TDI, and 2,6-TDI,
provides a threefold increase in sensitivity over conventional
columns while requiring only 1/3 of the solvent |
1 |
225-9057 |
| ISO-CHEK Certified HPLC Column ODS-2 for the determination of MDI oligomers. Provides a threefold
increase in sensitivity over conventional columns, while requiring
only a 1/3 of the solvent. |
1 |
225-9060 |
| ISO-CHEK Column Guard ODS-1, used to
protect ISO-CHEK HPLC column ODS-1 from premature plugging |
1 |
225-9058 |
| * |
ISO-CHEK cassettes must be analyzed by an ISO-CHEK-certified
laboratory. For a lab list see the SKC
ISO-CHEK Cassettes Laboratory Reference List.
|
| ‡ |
Haz-Mat shipping charges for air shipments only, ground shipments
exempt; not available for export.
|
| • |
Patent No. 4,961,916
|
| † |
IRSST (Institut de recherche en santé et en sécurité du
travail du Québec) |
ISO-CHEK
Isocyanate Sampling System Product Data Bulletin (PDF)
Material Safety Data Sheets
MSDS — MOPIP 1-(2-Methoxyphenyl)
Piperazine
MSDS — MAMA 9-(Methylaminomethyl)
Anthracene
MSDS — Toluene
References
1 OSHA Method 42 for the analysis
of diisocyanates
2 NIOSH Method 5221, Monomeric
Isocyanates
3 9-(N-methylaminomethyl) anthracene
4 1-(2-Pyridyl) piperazine
5 1-(2-Methoxypyridyl) piperazine
6 Poster Session, 1996 AIHce,
Paper #398: Meyer, P. and Czarnecki, M.
7 NIOSH Method 5221, Monomeric
Isocyanates
8, 9 Detection limits for ISO-CHEK
and OSHA Method 42 are µg/m3 in a 15-liter sample. For NIOSH
Method 5521, limits are stated as "per sample" with sample volume range
given as 5 to 500 liters, and limits were established using pure standards
without derivatizing reagent. For MDI, the first number of the pair for
ISO-CHEK is with a UV detector, the second is with a fluorescence detector.
10, 11 NIOSH Method 5221, Monomeric
Isocyanates
12 Recovery of spiked standards
by analysts is not associated with method
NA Data not available or determined
® ISO-CHEK is a registered trademark of Omega Speciality
Instrument Co.
This page was last modified March 6, 2007
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